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Scientists have taken a significant step forward in their search for the origin of a progressive eye condition which causes sight loss and can lead to corneal transplant. A new study into keratoconus by an international team of researchers, including a University of Leeds group led by Chris Inglehearn, Professor of Molecular Ophthalmology in the […]

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HSE University researchers have become the first in the world to discover genetic predisposition to severe COVID-19. The results of the study were published in the journal Frontiers in Immunology. T-cell immunity is one of the key mechanisms used by the human body to fight virus infections. The staging ground for cell immunity development is […]

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Strategies based on the use of gene therapy to mitigate the effects of mutations that cause blindness are undergoing rapid development. Novel gene vectors now achieve widespread gene delivery and reduce the risks associated with these approaches. The incidence of genetic mutations that result in rapid deterioration of the ability to see is larger than […]

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Cancer researcher Rita Fior uses zebrafish to study human cancer. Though this may seem like an unlikely match, her work shows great promise with forthcoming applications in personalized medicine. The basic principle of Fior's approach relies on transplanting human cancer cells into dozens of zebrafish larvae. The fish then serve as "living test tubes" where […]

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Genetic mutations which occur naturally during the earliest stages of an embryo’s development can cause the severe birth defect spina bifida, finds a new experimental study in mice led by UCL scientists. The research, bupropion breastfeeding published in Nature Communications, explains for the first time how a ‘mosaic mutation’ – a mutation which is not […]

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One day, physicians may be able to look at an African American’s skin color, and with the help of other determinants, know if prescribing vitamin D supplements would lower that person’s risk of getting cancers of the prostate, side effects of too high dose of levothyroxine colon, rectum or breast. “We should not shy from […]

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Novel genetic associations could pave the way for early interventions and personalized treatment of an incurable condition. Scientists from the University of Bergen (Norway) and Karolinska Institutet (Sweden) have discovered the genes involved in autoimmune Addison's disease, a condition where the body's immune systems destroys the adrenal cortex leading to a life-threatening hormonal deficiency of […]

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The RNA World hypothesis states that before the evolution of protein synthesis, the world was made up of RNA. There is growing evidence to support this hypothesis, but the question remains; “How was the RNA able to be replicated without enzymes?”.The answer may be answered by non-enzymatic primer extension. Juan Gaertner | Shutterstock The process […]