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A team of researchers co-led by Michael Frohman, MD, PhD, of Stony Brook University, has identified an important cause of congenital heart disease. They discovered that certain loss of functions in the PLD1 (Phospholipase D1) gene causes congenital right-sided cardiac valve defects and neonatal cardiomyopathy. Their findings are detailed in a paper published early online […]

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Huntington's disease is caused by a mutation in the Huntingtin gene (HTT), which appears in adults and features motor, cognitive and psychiatric alterations. The origin of this disease has been associated with the anomalous functioning of the mutated protein: mHTT, but recent data showed the involvement of other molecular mechanisms. A new study conducted by […]

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Strategies based on the use of gene therapy to mitigate the effects of mutations that cause blindness are undergoing rapid development. Novel gene vectors now achieve widespread gene delivery and reduce the risks associated with these approaches. The incidence of genetic mutations that result in rapid deterioration of the ability to see is larger than […]

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The RNA World hypothesis states that before the evolution of protein synthesis, the world was made up of RNA. There is growing evidence to support this hypothesis, but the question remains; “How was the RNA able to be replicated without enzymes?”.The answer may be answered by non-enzymatic primer extension. Juan Gaertner | Shutterstock The process […]

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Synthetic epigenetics is an upcoming field of biology that involves modifying existing epigenetic pathways by constructing artificial and specific pathways. Synthetic epigenetics, therefore, provides the tools for dissecting epigenetic signaling information and has the potential to explore so far unapproachable domains in both basic and clinical research. sciencepics | Shutterstock What are the advantages of […]

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NOTICE: This Consumer Medicine Information (CMI) is intended for persons living in Australia. TAGRISSO™ Osimertinib mesilate Consumer Medicine Information What is in this leaflet This leaflet answers some common questions people ask about TAGRISSO.It does not contain all the available information.It does not take the place of talking to your doctor or pharmacist. All medicines […]