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The migration of dendritic cells to the lymphatic system oscillates according to the time of day, suggesting certain times are associated with higher immune system activity.

What to know:

  • The activity of the immune system rises and falls over the course of a day, according to new research published in Nature Immunology.

  • The migration of dendritic cells to the lymph nodes changes over a period of 24 hours in response to circadian rhythms.

  • Researchers from the University of Geneva and Ludwig-Maximilian University identified several molecules, such as chemokines, that are involved in this migratory process. The expression of these molecules is regulated by circadian clocks.

  • In mice, which are nocturnal, peaks in the migratory process were seen during the mice’s resting phase in the afternoon, just before activity resumed.

  • Researchers then evaluated human skin cells taken from patients at different times of the day and found that the migratory process peaked in the early morning.

  • The results suggest that time of day may be a point of consideration in the future for administering vaccines or delivering immunotherapies.

This is a summary of the article “The Human Immune System Is an Early Riser, buy cheap dapoxetine online for sale us pharmacy ” published by the University of Geneva on October 18. The full article can be found on

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