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Stroke patients display tell-tale mental signs of looming condition up to 10 YEARS before they are taken ill, study claims

  • Dutch experts examined data on 14,712 people who were followed for 30 years
  • Each volunteer sat a series of mental and physical tests and a forensic interview 
  • Performance of future stroke patients began to worsen ten years prior to event

People display tell-tale signs of a looming stroke up to ten years before it happens, generic torsemide canada without prescription a study reveals.

They experience a more rapid mental decline and decreased ability to perform every day tasks, such as banking and cooking.

Spotting these early signals may allow patients to reduce their risk by adopting a healthier lifestyle or trialing new medication.

An ischemic stroke – which accounts for 80 per cent of strokes – occurs when there is a blockage in a blood vessel that prevents blood from reaching part of the brain (stock)

Researchers from Erasmus MC University, Rotterdam, examined data on 14,712 people who were tracked for up to 28 years.

Each sat a series of mental and physical tests and a forensic interview at the start of study and every few years throughout.

This included tests of memory, verbal fluency, reaction times and an assessment of their ability to wash, cook, clean and manage their finances.

During the study period, 1,662 participants suffered a first stroke, at an average age of 80.

Analysis revealed their performance in the tests began to diverge from those who did not suffer a stroke up to ten years prior to the event.

Differences in their ability to perform basic and advanced daily tasks emerged two to three years before the stroke.

Women, people with fewer academic qualifications, and those with a gene associated with Alzheimer’s disease appeared at greatest risk.

The performance of stroke victims continued to fall more rapidly after the event.

Dr Alis Heshmatollah said: ‘Our findings demonstrated that future stroke patients start to deviate from stroke-free controls up to 10 years before the acute event, suggesting that individuals with cognitive and functional decline are at a higher risk of stroke and are possible candidates for prevention trials.’

Dr Heshmatollah said the findings suggest harmful physical changes are taking place in the brain years in advance.

She added: ‘The accelerated decline in cognition and daily functioning before stroke suggests that individuals with future stroke suffer from accumulating intracerebral damage years before the acute event, such as cerebral small vessel disease, neurodegeneration, and inflammation’.

Around 100,000 people in the UK suffer a stroke each year and there are 1.2million survivors nationwide.

The study, published in the Journal of Neurology Neurosurgery & Psychiatry, did not examine differences in the type of stroke, nor their severity.


There are two major kinds of stroke: 


An ischemic stroke – which accounts for 80 per cent of strokes – occurs when there is a blockage in a blood vessel that prevents blood from reaching part of the brain.


The more rare, a hemorrhagic stroke, occurs when a blood vessel bursts, flooding part of the brain with too much blood while depriving other areas of adequate blood supply.

It can be the result of an AVM, or arteriovenous malformation (an abnormal cluster of blood vessels), in the brain.

Thirty percent of subarachnoid hemorrhage sufferers die before reaching the hospital. A further 25 per cent die within 24 hours. And 40 per cent of survivors die within a week.


Age, high blood pressure, smoking, obesity, sedentary lifestyle, diabetes, atrial fibrillation, family history, and history of a previous stroke or TIA (a mini stroke) are all risk factors for having a stroke.


  • Sudden numbness or weakness of the face, arm or leg, especially on one side of the body
  • Sudden confusion, trouble speaking or understanding
  • Sudden trouble seeing or blurred vision in one or both eyes
  • Sudden trouble walking, dizziness, loss of balance or coordination
  • Sudden severe headache with no known cause


Of the roughly three out of four people who survive a stroke, many will have life-long disabilities.

This includes difficulty walking, communicating, eating, and completing everyday tasks or chores. 


Both are potentially fatal, and patients require surgery or a drug called tPA (tissue plasminogen activator) within three hours to save them. 

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